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The multifaceted biology of plasmacytoid dendritic cells
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Journal Article
The multifaceted biology of plasmacytoid dendritic cells
2015
Overview
Key Points
This Review provides an introduction to human and mouse plasmacytoid dendritic cells (pDCs) and their importance in the immune system.
We discuss the phenotypes of human and mouse pDCs and the mechanisms that control their development.
We explain how pDCs sense nucleic acids and microbial products, as well as their potential role in viral infections and diseases characterized by a type I interferon (IFN) signature, such as systemic lupus erythematosus, psoriasis and type 1 diabetes.
We discuss the emerging field of microbiome research and how pDCs can shape mucosal immune responses.
We describe how pDCs can be tolerogenic or immunogenic in the context of cancer.
Finally, we end by raising several questions regarding the validity of targeting pDCs or their type I IFN production as a therapeutic strategy.
This Review details our current understanding of the biology of plasmacytoid dendritic cells (pDCs). The authors describe the mechanisms controlling the development and functions of pDCs and discuss their roles in infection, inflammatory disease and cancer.
Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.
Publisher
Nature Publishing Group UK,Nature Publishing Group
