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Uncovering the role of 5-hydroxymethylcytosine in the epigenome
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Journal Article
Uncovering the role of 5-hydroxymethylcytosine in the epigenome
2012
Overview
The recent discovery of enzymes that convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) in mammalian genomes has led to a surge of interesting possible functions for 5hmC, from the regulation of DNA methylation to the biology of pluripotency, differentiation and brain function.
Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Blastocyst Inner Cell Mass - metabolism
/ Cell Differentiation - genetics
/ Cytosine
/ Cytosine - analogs & derivatives
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - metabolism
/ Embryonic Stem Cells - cytology
/ Embryonic Stem Cells - enzymology
/ Enzymes
/ Epigenesis, Genetic - genetics
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Developmental
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomes
/ Humans
/ Mice
/ progress
/ Proteins
/ Proto-Oncogene Proteins - genetics
