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Highly Conserved Protective Epitopes on Influenza B Viruses
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Highly Conserved Protective Epitopes on Influenza B Viruses
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Journal Article
Highly Conserved Protective Epitopes on Influenza B Viruses
2012
Overview
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody—based immunotherapy and \"universal\" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody—based treatments and a universal flu vaccine for all influenza A and B viruses.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Antibodies, Monoclonal - chemistry
/ Antibodies, Monoclonal - immunology
/ Antibodies, Neutralizing - chemistry
/ Antibodies, Neutralizing - immunology
/ Antigens
/ Biological and medical sciences
/ birds
/ Epitopes
/ H1N1 subtype influenza A virus
/ H3N2 subtype influenza A virus
/ Hemagglutinin Glycoproteins, Influenza Virus - immunology
/ hosts
/ Human
/ Humans
/ Immunodominant Epitopes - chemistry
/ Immunodominant Epitopes - immunology
/ Influenza B virus - immunology
/ Influenza Vaccines - immunology
/ Mice
/ Orthomyxoviridae Infections - prevention & control
/ Pigs
/ Strain
/ swine
/ Vaccines
/ Viral diseases of the respiratory system and ent viral diseases
/ Viruses
