Journal Article

Assertive outreach treatment versus care as usual for the treatment of high-need, high-cost alcohol related frequent attenders: study protocol for a randomised controlled trial

Currell, E., Khadjesari, Z., Jennings, S., O’Toole, J., Drummond, C., Coulton, S., Winnington, J., Deluca, P., Kimergård, A., Byford, S., Finch, E., Fincham-Campbell, S., Dunne, J., Blackwood, R., Wolstenholme, A.

2020

Overview

Background Alcohol-related hospital admissions have doubled in the last ten years to > 1.2 m per year in England. High-need, high-cost (HNHC) alcohol-related frequent attenders (ARFA) are a relatively small subgroup of patients, having multiple admissions or attendances from alcohol during a short time period. This trial aims to test the effectiveness of an assertive outreach treatment (AOT) approach in improving clinical outcomes for ARFA, and reducing resource use in the acute setting. Methods One hundred and sixty ARFA patients will be recruited and following baseline assessment, randomly assigned to AOT plus care as usual (CAU) or CAU alone in equal numbers. Baseline assessment includes alcohol consumption and related problems, physical and mental health comorbidity and health and social care service use in the previous 6 months using standard validated tools, plus a measure of resource use. Follow-up assessments at 6 and 12 months after randomization includes the same tools as baseline plus standard measure of patient satisfaction. Outcomes for CAU + AOT and CAU at 6 and 12 months will be compared, controlling for pre-specified baseline measures. Primary outcome will be percentage of days abstinent at 12 months. Secondary outcomes include emergency department (ED) attendance, number and length of hospital admissions, alcohol consumption, alcohol-related problems, other health service use, mental and physical comorbidity 6 and 12 months post intervention. Health economic analysis will estimate the economic impact of AOT from health, social care and societal perspectives and explore cost-effectiveness in terms of quality adjusted life years and alcohol consumption at 12-month follow-up. Discussion AOT models piloted with alcohol dependent patients have demonstrated significant reductions in alcohol consumption and use of unplanned National Health Service (NHS) care, with increased engagement with alcohol treatment services, compared with patients receiving CAU. While AOT interventions are costlier per case than current standard care in the UK, the rationale for targeting HNHC ARFAs is because of their disproportionate contribution to overall alcohol burden on the NHS. No previous studies have evaluated the clinical and cost-effectiveness of AOT for HNHC ARFAs: this randomized controlled trial (RCT) targeting ARFAs across five South London NHS Trusts is the first. Trial registration International standard randomized controlled trial number (ISRCTN) registry: ISRCTN67000214 , retrospectively registered 26/11/2016.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Addictions / Adult / Alcohol / Alcohol Drinking - epidemiology / Alcohol Drinking - prevention & control / Alcohol use / Alcohol-Related Disorders - economics / Alcohol-Related Disorders - therapy / Alcoholics / Alcoholism / Alcohols / Assertive outreach treatment / Biostatistics / Care and treatment / Clinical trials / Community support / Comorbidity / Cost analysis / Cost control / Cost-Benefit Analysis / Dependence / Drinking (Alcoholic beverages) / Economic analysis / Economic impact / Economics / Emergency medical care / Emergency medical services / Emergency Service, Hospital - economics / Emergency Service, Hospital - statistics & numerical data / Environmental Health / Epidemiology / Facilities and Services Utilization - economics / Facilities and Services Utilization - statistics & numerical data / Female / Frequent attenders / Health aspects / Hospital admission and discharge / Hospitalization - economics / Hospitalization - statistics & numerical data / Humans / International standards / Intervention / Intervention (Psychology) / London - epidemiology / Male / Medicine / Medicine & Public Health / Mental disorders / Mental health / Mental health care / Methods / Multimorbidity / Outreach services / Patient satisfaction / Patients / Public Health / Qualitative research / Randomized controlled trial / Randomized Controlled Trials as Topic / Risk factors / Setting (Literature) / Socialized medicine / State Medicine - economics / State Medicine - statistics & numerical data / Study Protocol / Substance abuse treatment / Time / Treatment Outcome / Vaccine