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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
by
de Aguiar Roza, Bartira
, Poncelet, Alain Jean
, Bernard, Andrée
, Epstein, Flavio
, Dobbels, Fabienne
, De Simone, Paolo
, Almenar-Bonet, Luis
, Parry, Gareth
, Horvath, Eva
, Mohacsi, Paul
, Flattery, Maureen
, Fisher, Grant
, Firouzi, Ashi
, Berben, Lut
, Kao, Andrew
, Haddad, Haissam
, Sebbag, Laurent
, Saint-Gerons, Carmen Segura
, Cupples, Sandra
, Scalso de Almeida, Samira
, Molina, Maria
, Ohler, Linda
, Helmy, Remon
, Ludrosky, Kristin
, Barone, Fernanda
, Harkess, Michelle
, Russell, Cynthia L.
, Coleman, Bernice
, Michel, Magali
, Albert, Nancy
, Potena, Luciano
, Livi, Ugolino
, Kozuszko, Stella
, Brossa-Loidi, Vicens
, Canales, Karyn Ryan
, Kugler, Christiane
, Kaan, Annemarie
, Trammell, Jacqueline
, Miller, Tara
, Doesch, Andreas
, Riotto, Cheryl
, St Clair, Katherine
, Van Cleemput, Johan
, Crespo-Leiro, Marisa G.
, De Geest, Sabina
, Maddicks-Law, Joanne
, Ayoub, Andrea Cotait
, Segovia-Cubero, Javier
, Groenewoud, Albert
, Denhaerynck, Kris
in
[SDV]Life Sciences [q-bio]
/ ADHERENCE
/ Adult
/ Aged
/ Arzneiverordnung
/ co-medications
/ co-medications; cross-sectional; heart transplantation; immunosuppressants; international; medication adherence; Pharmacology; Pharmacology (medical)
/ cross-sectional
/ Cross-Sectional Studies
/ Data analysis
/ Data collection
/ Drug dosages
/ Female
/ Heart
/ Heart transplantation
/ Heart Transplantation - methods
/ Herztransplantation
/ Humans
/ immunosuppressants
/ Immunosuppressive Agents
/ Immunosuppressive Agents - administration & dosage
/ Immunosuppressive Agents - therapeutic use
/ Immunsuppressivum
/ International
/ Life Sciences & Biomedicine
/ Logistic Models
/ Male
/ Medication Adherence
/ Medication Adherence - statistics & numerical data
/ Middle Aged
/ Observatories
/ Patient compliance
/ Patients
/ Pharmacology & Pharmacy
/ Prevalence
/ Querschnitt
/ Science & Technology
/ Self Report
/ Software
/ Studies
/ Transplants & implants
2019
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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
by
de Aguiar Roza, Bartira
, Poncelet, Alain Jean
, Bernard, Andrée
, Epstein, Flavio
, Dobbels, Fabienne
, De Simone, Paolo
, Almenar-Bonet, Luis
, Parry, Gareth
, Horvath, Eva
, Mohacsi, Paul
, Flattery, Maureen
, Fisher, Grant
, Firouzi, Ashi
, Berben, Lut
, Kao, Andrew
, Haddad, Haissam
, Sebbag, Laurent
, Saint-Gerons, Carmen Segura
, Cupples, Sandra
, Scalso de Almeida, Samira
, Molina, Maria
, Ohler, Linda
, Helmy, Remon
, Ludrosky, Kristin
, Barone, Fernanda
, Harkess, Michelle
, Russell, Cynthia L.
, Coleman, Bernice
, Michel, Magali
, Albert, Nancy
, Potena, Luciano
, Livi, Ugolino
, Kozuszko, Stella
, Brossa-Loidi, Vicens
, Canales, Karyn Ryan
, Kugler, Christiane
, Kaan, Annemarie
, Trammell, Jacqueline
, Miller, Tara
, Doesch, Andreas
, Riotto, Cheryl
, St Clair, Katherine
, Van Cleemput, Johan
, Crespo-Leiro, Marisa G.
, De Geest, Sabina
, Maddicks-Law, Joanne
, Ayoub, Andrea Cotait
, Segovia-Cubero, Javier
, Groenewoud, Albert
, Denhaerynck, Kris
in
[SDV]Life Sciences [q-bio]
/ ADHERENCE
/ Adult
/ Aged
/ Arzneiverordnung
/ co-medications
/ co-medications; cross-sectional; heart transplantation; immunosuppressants; international; medication adherence; Pharmacology; Pharmacology (medical)
/ cross-sectional
/ Cross-Sectional Studies
/ Data analysis
/ Data collection
/ Drug dosages
/ Female
/ Heart
/ Heart transplantation
/ Heart Transplantation - methods
/ Herztransplantation
/ Humans
/ immunosuppressants
/ Immunosuppressive Agents
/ Immunosuppressive Agents - administration & dosage
/ Immunosuppressive Agents - therapeutic use
/ Immunsuppressivum
/ International
/ Life Sciences & Biomedicine
/ Logistic Models
/ Male
/ Medication Adherence
/ Medication Adherence - statistics & numerical data
/ Middle Aged
/ Observatories
/ Patient compliance
/ Patients
/ Pharmacology & Pharmacy
/ Prevalence
/ Querschnitt
/ Science & Technology
/ Self Report
/ Software
/ Studies
/ Transplants & implants
2019
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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
by
de Aguiar Roza, Bartira
, Poncelet, Alain Jean
, Bernard, Andrée
, Epstein, Flavio
, Dobbels, Fabienne
, De Simone, Paolo
, Almenar-Bonet, Luis
, Parry, Gareth
, Horvath, Eva
, Mohacsi, Paul
, Flattery, Maureen
, Fisher, Grant
, Firouzi, Ashi
, Berben, Lut
, Kao, Andrew
, Haddad, Haissam
, Sebbag, Laurent
, Saint-Gerons, Carmen Segura
, Cupples, Sandra
, Scalso de Almeida, Samira
, Molina, Maria
, Ohler, Linda
, Helmy, Remon
, Ludrosky, Kristin
, Barone, Fernanda
, Harkess, Michelle
, Russell, Cynthia L.
, Coleman, Bernice
, Michel, Magali
, Albert, Nancy
, Potena, Luciano
, Livi, Ugolino
, Kozuszko, Stella
, Brossa-Loidi, Vicens
, Canales, Karyn Ryan
, Kugler, Christiane
, Kaan, Annemarie
, Trammell, Jacqueline
, Miller, Tara
, Doesch, Andreas
, Riotto, Cheryl
, St Clair, Katherine
, Van Cleemput, Johan
, Crespo-Leiro, Marisa G.
, De Geest, Sabina
, Maddicks-Law, Joanne
, Ayoub, Andrea Cotait
, Segovia-Cubero, Javier
, Groenewoud, Albert
, Denhaerynck, Kris
in
[SDV]Life Sciences [q-bio]
/ ADHERENCE
/ Adult
/ Aged
/ Arzneiverordnung
/ co-medications
/ co-medications; cross-sectional; heart transplantation; immunosuppressants; international; medication adherence; Pharmacology; Pharmacology (medical)
/ cross-sectional
/ Cross-Sectional Studies
/ Data analysis
/ Data collection
/ Drug dosages
/ Female
/ Heart
/ Heart transplantation
/ Heart Transplantation - methods
/ Herztransplantation
/ Humans
/ immunosuppressants
/ Immunosuppressive Agents
/ Immunosuppressive Agents - administration & dosage
/ Immunosuppressive Agents - therapeutic use
/ Immunsuppressivum
/ International
/ Life Sciences & Biomedicine
/ Logistic Models
/ Male
/ Medication Adherence
/ Medication Adherence - statistics & numerical data
/ Middle Aged
/ Observatories
/ Patient compliance
/ Patients
/ Pharmacology & Pharmacy
/ Prevalence
/ Querschnitt
/ Science & Technology
/ Self Report
/ Software
/ Studies
/ Transplants & implants
2019
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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
Journal Article
Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
2019
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Overview
To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients.
MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries.
MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30–1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13–4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49–4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36–11.20).
The observed MNA necessitates adherence-enhancing interventions encompassing the entire post–heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.
Publisher
Elsevier Inc,Elsevier BV,Elsevier Limited
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