Asset Details
Do you wish to reserve the book?
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Do you wish to request the book?
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
2013
Overview
BM mesenchymal stromal cells (BM-MSCs) support multiple myeloma (MM) cell growth, but little is known about the putative mechanisms by which the BM microenvironment plays an oncogenic role in this disease. Cell-cell communication is mediated by exosomes. In this study, we showed that MM BM-MSCs release exosomes that are transferred to MM cells, thereby resulting in modulation of tumor growth in vivo. Exosomal microRNA (miR) content differed between MM and normal BM-MSCs, with a lower content of the tumor suppressor miR-15a. In addition, MM BM-MSC-derived exosomes had higher levels of oncogenic proteins, cytokines, and adhesion molecules compared with exosomes from the cells of origin. Importantly, whereas MM BM-MSC-derived exosomes promoted MM tumor growth, normal BM-MSC exosomes inhibited the growth of MM cells. In summary, these in vitro and in vivo studies demonstrated that exosome transfer from BM-MSCs to clonal plasma cells represents a previously undescribed and unique mechanism that highlights the contribution of BM-MSCs to MM disease progression.
Publisher
American Society for Clinical Investigation
Subject
/ Animals
/ Bone Marrow Neoplasms - metabolism
/ Bone Marrow Neoplasms - secondary
/ Cloning
/ Female
/ Humans
/ Kinases
/ Mesenchymal Stem Cell Transplantation
/ Mesenchymal Stromal Cells - metabolism
/ Mesenchymal Stromal Cells - physiology
/ Mice
/ Multiple Myeloma - metabolism
/ Multiple Myeloma - pathology
/ Plasma
/ Proteins
/ Tumors
