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Prospective identification of myogenic endothelial cells in human skeletal muscle
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Prospective identification of myogenic endothelial cells in human skeletal muscle
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Journal Article
Prospective identification of myogenic endothelial cells in human skeletal muscle
2007
Overview
We document anatomic, molecular and developmental relationships between endothelial and myogenic cells within human skeletal muscle. Cells coexpressing myogenic and endothelial cell markers (CD56, CD34, CD144) were identified by immunohistochemistry and flow cytometry. These myoendothelial cells regenerate myofibers in the injured skeletal muscle of severe combined immunodeficiency mice more effectively than CD56
+
myogenic progenitors. They proliferate long term, retain a normal karyotype, are not tumorigenic and survive better under oxidative stress than CD56
+
myogenic cells. Clonally derived myoendothelial cells differentiate into myogenic, osteogenic and chondrogenic cells in culture. Myoendothelial cells are amenable to biotechnological handling, including purification by flow cytometry and long-term expansion
in vitro
, and may have potential for the treatment of human muscle disease.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Child
/ Endothelial Cells - cytology
/ Fundamental and applied biological sciences. Psychology
/ Health. Pharmaceutical industry
/ Humans
/ Industrial applications and implications. Economical aspects
/ Mice
/ Muscle, Skeletal - physiology
/ Rodents
