Asset Details
Do you wish to reserve the book?
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
Do you wish to request the book?
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
2009
Overview
Earlier, mapping of the 9p23–24 amplicon in esophageal cancer cell lines led us to the positional cloning of gene amplified in squamous cell carcinoma 1 (
GASC1
), which encodes a nuclear protein with a Jumonji C domain that catalyzes lysine (K) demethylation of histones. However, the transforming roles of GASC1 in breast cancer remain to be determined. In this study, we identified
GASC1
as one of the amplified genes for the 9p23–24 region in breast cancer, particularly in basal-like subtypes. The levels of GASC1 transcript expression were significantly higher in aggressive, basal-like breast cancers compared with nonbasal-like breast cancers. Our
in vitro
assays demonstrated that GASC1 induces transformed phenotypes, including growth factor-independent proliferation, anchorage-independent growth, altered morphogenesis in Matrigel, and mammosphere forming ability, when overexpressed in immortalized, nontransformed mammary epithelial MCF10A cells. Additionally, GASC1 demethylase activity regulates the expression of genes critical for stem cell self-renewal, including NOTCH1, and may be linked to the stem cell phenotypes in breast cancer. Thus,
GASC1
is a driving oncogene in the 9p23–24 amplicon in human breast cancer and targeted inhibition of GASC1 histone demethylase in cancer could provide potential new avenues for therapeutic development.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Breast Neoplasms - pathology
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Cell Transformation, Neoplastic
/ Cloning
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Genomics
/ Gynecology. Andrology. Obstetrics
/ Histones
/ Humans
/ Jumonji Domain-Containing Histone Demethylases - genetics
/ Lysine
/ Medicine
/ Molecular and cellular biology
/ Oncology
/ Tumors
