Journal Article

Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort

Wang, Shaohua, Yan, Meichen, Pang, Mingmin, Yi, Fan, Zhao, Shaohua, Cao, Xuelei, Yang, Xiaorong, Xu, Yue, Wang, Hao

2023

Overview

Background The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various indicators of systemic inflammation and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia in the UK Biobank cohort. Methods After excluding ineligible participants, a total of 478,524 eligible individuals (46.75% male, aged 40–69 years) were enrolled in the study to assess the association between systemic inflammatory indicators and each type of arrhythmia. Results After covariates were fully adjusted, CRP levels were found to have an essentially linear positive correlation with the risk of various arrhythmias; neutrophil count, monocyte count, and NLR showed a non-linear positive correlation; and lymphocyte count, SII, PLR, and LMR showed a U-shaped association. VA showed the strongest association with systemic inflammation indicators, and it was followed sequentially by AF and bradyarrhythmia. Conclusions Multiple systemic inflammatory indicators showed strong associations with the onset of AF, VA, and bradyarrhythmia, of which the latter two have been rarely studied. Active systemic inflammation management might have favorable effects in reducing the arrhythmia burden and further randomized controlled studies are needed.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Alcohol / Angina pectoris / Arrhythmia / Arrhythmias, Cardiac - epidemiology / Atrial fibrillation / Biobanks / Biological Specimen Banks / Biomarkers / Biomedicine / Blood platelets / Blood pressure / Blood-based inflammation markers / Body mass index / Bradyarrhythmia / Bradycardia / Cardiac arrhythmia / Cardiovascular diseases / Care and treatment / Cell number / Chronic illnesses / Comorbidity / Correlation / Diabetes / Diagnosis / Female / Heart attacks / Humans / Hyperlipidemia / Hypertension / Indicators / Inflammation / Inflammation - epidemiology / Leukocytes (neutrophilic) / Lymphocytes / Male / Medicine / Medicine & Public Health / Monocytes / Neutrophils / Population / Research Article / Systemic inflammation / Tumors / UK Biobank / United Kingdom - epidemiology / Values / Variables / Ventricle / Ventricular arrhythmia