Journal Article

Glucocorticoids and breast cancer risk

Hirko, Kelly A., Eliassen, A. Heather

2021

Overview

An additional strength of this study was the inclusion of comprehensive information on potential confounders including body mass index, alcohol consumption, family history of breast cancer, and use of nonsteroidal anti-inflammatory medication; factors which were not considered in prior population registry-based studies in Denmark [5, 6] where no associations between receipt of glucocorticoid prescription and breast cancer risk were observed. [...]given that ER-positive tumors tend to be less aggressive than ER-negative tumors, the inverse associations observed for early stage disease may reflect the preponderance of ER-positive tumors in this group. [...]this is the first study to evaluate whether the relationship between glucocorticoids and breast cancer differs according to hormone receptor status, histology, and tumor stage. [...]results need to be confirmed in large epidemiologic studies with detailed information on tumor characteristics to address the small number of in situ, ER-negative, and late stage breast cancers included in the current study.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Arthritis / Biomedicine / Body mass / Body mass index / Body size / Breast cancer / Breast Neoplasms - epidemiology / Commentary / Complications and side effects / Corticosteroids / Development and progression / Epidemiology / Estrogen receptor / Estrogens / Etiology / Female / Genetics / Glucocorticoids / Glucocorticoids - adverse effects / Health aspects / Health risks / Histology / Humans / Inflammation / Insulin resistance / Mammography / Medicine / Medicine & Public Health / Population studies / Postmenopausal women / Risk factors / Surveillance / Tumors / Womens health