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STINGing away the pain: the role of interferon-stimulated genes
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Journal Article
STINGing away the pain: the role of interferon-stimulated genes
2024
Overview
Pain and inflammation are biologically intertwined responses that warn the body of potential danger. In this issue of the JCI , Defaye, Bradaia, and colleagues identified a functional link between inflammation and pain, demonstrating that inflammation-induced activation of stimulator of IFN genes (STING) in dorsal root ganglia nociceptors reduced pain-like behaviors in a rodent model of inflammatory pain. Utilizing mice with a gain-of-function STING mutation, Defaye, Bradaia, and colleagues identified type I IFN regulation of voltage-gated potassium channels as the mechanism of this pain relief. Further investigation into mechanisms by which proinflammatory pathways can reduce pain may reveal druggable targets and insights into new approaches for treating persistent pain.
Publisher
American Society for Clinical Investigation
Subject
/ Biological response modifiers
/ Complications and side effects
/ Ganglia, Spinal - metabolism
/ Genes
/ Humans
/ Interferon Type I - genetics
/ Interferon Type I - immunology
/ Interferon Type I - metabolism
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Mice
/ Pain
/ Potassium Channels, Voltage-Gated - genetics
