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High-grade large cell neuroendocrine carcinoma of the esophagus: a case report and review of the literature
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High-grade large cell neuroendocrine carcinoma of the esophagus: a case report and review of the literature
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Journal Article
High-grade large cell neuroendocrine carcinoma of the esophagus: a case report and review of the literature
2023
Overview
Background
Neuroendocrine carcinomas are extremely rare in the esophagus as they represent less than 0.04% of all neuroendocrine tumors. To date, only 14 cases of poorly differentiated, high-grade esophageal NEC have been described in the literature. The majority of these patients presented with typical dysphagia symptoms. Due to its rarity, no standardized guidelines have been proposed to treat esophageal neuroendocrine carcinoma, although general recommendations suggest surgery with adjuvant chemoradiotherapy as the treatment of choice.
Case presentation
A 67-year-old previously healthy White male presented with a year-long intermittent nonspecific retrosternal discomfort, with the absence of any other symptoms. Esophagogastroduodenoscopy revealed an ulcerative mass in his lower esophagus, with concern of malignancy. Endoscopic ultrasound-guided biopsy revealed poorly differentiated neuroendocrine carcinoma of the esophagus with metastasis to a diaphragmatic lymph node. He was treated with neoadjuvant chemoradiation followed by surgery, and he has been in remission for over 5 years.
Conclusion
Here, we review the literature and report a unique case of a patient with a vague presentation of esophageal neuroendocrine carcinoma as he enters his sixth year of survival following neoadjuvant chemoradiotherapy.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Alcohol
/ Cancer
/ Carcinoma, Neuroendocrine - diagnostic imaging
/ Carcinoma, Neuroendocrine - pathology
/ Carcinoma, Neuroendocrine - therapy
/ Esophageal Neoplasms - diagnostic imaging
/ Esophageal Neoplasms - pathology
/ Esophageal Neoplasms - therapy
/ Humans
/ Male
/ Medicine
/ Patients
