Journal Article

Multimodal-based machine learning strategy for accurate and non-invasive prediction of intramedullary glioma grade and mutation status of molecular markers: a retrospective study

Song, Dengpan, Man, Weitao, Lu, Yang, Meng, Zhe, Jing, Linkai, Zhang, Huifang, Xue, Ping, Zhang, Yupeng, Liu, Dongkang, Wang, Guihuai, Ma, Chao, Gao, Chuntian, Yang, Kaiyuan, Wang, Liyang, Guo, Fuyou

2023

Overview

Background Determining the grade and molecular marker status of intramedullary gliomas is important for assessing treatment outcomes and prognosis. Invasive biopsy for pathology usually carries a high risk of tissue damage, especially to the spinal cord, and there are currently no non-invasive strategies to identify the pathological type of intramedullary gliomas. Therefore, this study aimed to develop a non-invasive machine learning model to assist doctors in identifying the intramedullary glioma grade and mutation status of molecular markers. Methods A total of 461 patients from two institutions were included, and their sagittal (SAG) and transverse (TRA) T2-weighted magnetic resonance imaging scans and clinical data were acquired preoperatively. We employed a transformer-based deep learning model to automatically segment lesions in the SAG and TRA phases and extract their radiomics features. Different feature representations were fed into the proposed neural networks and compared with those of other mainstream models. Results The dice similarity coefficients of the Swin transformer in the SAG and TRA phases were 0.8697 and 0.8738, respectively. The results demonstrated that the best performance was obtained in our proposed neural networks based on multimodal fusion (SAG-TRA-clinical) features. In the external validation cohort, the areas under the receiver operating characteristic curve for graded (WHO I–II or WHO III–IV), alpha thalassemia/mental retardation syndrome X-linked ( ATRX ) status, and tumor protein p53 ( P53 ) status prediction tasks were 0.8431, 0.7622, and 0.7954, respectively. Conclusions This study reports a novel machine learning strategy that, for the first time, is based on multimodal features to predict the ATRX and P53 mutation status and grades of intramedullary gliomas. The generalized application of these models could non-invasively provide more tumor-specific pathological information for determining the treatment and prognosis of intramedullary gliomas.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Alpha thalassemia/mental retardation syndrome X-linked / Analysis / Biological markers / Biomarkers / Biomedicine / Biopsy / Brain Neoplasms - genetics / Care and treatment / Classification / Data acquisition / Deep learning / Diagnosis / Edema / Glioma / Glioma - diagnosis / Glioma - genetics / Gliomas / Health services / Hospitals / Humans / Intellectual disabilities / Intramedullary gliomas / Learning algorithms / Machine Learning / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Medicine / Medicine & Public Health / Methods / Multimodal / Mutation / Nervous system / Neural networks / p53 Protein / Patients / Prognosis / Radiomics / Research Article / Retrospective Studies / Spinal cord / Strategy / Thalassemia / Transformers / Tumor protein p53 / Tumor proteins / Tumor Suppressor Protein p53 - genetics / Tumors