Asset Details
Do you wish to reserve the book?
Arterial tortuosity syndrome causing recurrent transient ischemic attacks in young adult: a case report
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Arterial tortuosity syndrome causing recurrent transient ischemic attacks in young adult: a case report
Do you wish to request the book?
Arterial tortuosity syndrome causing recurrent transient ischemic attacks in young adult: a case report
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Arterial tortuosity syndrome causing recurrent transient ischemic attacks in young adult: a case report
2021
Overview
Background
Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive disorder characterized by elongated and tortuous arteries. Although ATS showed a significant clinical and pathophysiological overlap with other syndromes involving connective tissues, only few cases of cerebrovascular events related to this syndrome have been described so far.
Case presentation
We report the case of a 33-years-old male diagnosed with ATS since childhood, that experienced three sudden episodes of expressive aphasia and right hemiparesis with spontaneous resolution. He was treated with recombinant tissue plasminogen activator (r-TPA) at a dosage of 0.9 mg/kg with a complete recovery. Brain Magnetic Resonance Imaging (MRI) showed the absence of acute ischemic lesions and the patient was diagnosed with recurrent transient ischemic attacks (TIA).
Intracranial and supra-aortic trunks Magnetic Resonance Angiography (MRA) and Angio-CT scan of the thoracic and abdominal aorta showed marked vessel tortuosity without stenosis.
To our knowledge, this is the first reported case of an ATS patient with TIA in young age that was treated with intravenous thrombolysis with recombinant plasminogen activator.
Conclusion
Our report strengthens the relationship between ATS and juvenile cerebrovascular events, suggesting that an extensive study of body vessels in order to detect potential stenoses or occlusions in these cases is needed.
The greater predisposition to cerebrovascular events in ATS could benefit from a more aggressive primary and secondary prevention therapy.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aorta
/ Aphasia
/ Arterial tortuosity syndrome
/ Arteries
/ Children
/ Complications and side effects
/ Glucose
/ Humans
/ Ischemia
/ Ischemic Attack, Transient - drug therapy
/ Ischemic Attack, Transient - etiology
/ Joint Instability - complications
/ Joint Instability - drug therapy
/ Male
/ Medicine
/ Mutation
/ Paresis
/ Patients
/ Skin Diseases, Genetic - complications
/ Skin Diseases, Genetic - drug therapy
/ Stenosis
/ Stroke
/ Thorax
/ Tissue Plasminogen Activator
/ Vascular Malformations - complications
