Journal Article

The effect of deep and awake extubation on emergence agitation after nasal surgery: a randomized controlled trial

Qiu, Lin, Sun, Zhujie, Lu, Lu, Shi, Jinya, Lao, Wei, Li, Jingjie, Liu, Jinxing, Zhou, Xuhui, Suo, Lulu

2024

Overview

Background Post-anesthetic emergence agitation is common after general anesthesia and may cause adverse consequences, such as injury as well as respiratory and circulatory complications. Emergence agitation after general anesthesia occurs more frequently in nasal surgery than in other surgical procedures. This study aimed to assess the occurrence of emergence agitation in patients undergoing nasal surgery who were extubated under deep anesthesia or when fully awake. Methods A total of 202 patients (18–60 years, American Society of Anesthesiologists classification: I–II) undergoing nasal surgery under general anesthesia were randomized 1:1 into two groups: a deep extubation group (group D) and an awake extubation group (group A). The primary outcome was the incidence of emergence agitation. The secondary outcomes included number of emergence agitations, sedation score, vital signs, and incidence of adverse events. Results The incidence of emergence agitation was lower in group D than in group A (34.7% vs. 72.8%; p  < 0.001). Compared to group A, patients in group D had lower Richmond Agitation-Sedation Scale scores, higher Ramsay sedation scores, fewer agitation episodes, and lower mean arterial pressure when extubated and 30 min after surgery, whereas these indicators did not differ 90 min after surgery. There was no difference in the incidence of adverse events between the two groups. Conclusions Extubation under deep anesthesia can significantly reduce emergence agitation after nasal surgery under general anesthesia without increasing the incidence of adverse events. Trial registration Registered in Clinicaltrials.gov (NCT04844333) on 14/04/2021.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Adult / Adverse events / Agitation / Airway Extubation - methods / Airway management / Anesthesia / Anesthesia Recovery Period / Anesthesia, General - methods / Anesthesiology / Blood pressure / Clinical trials / Complications and side effects / Critical Care Medicine / Delirium / Dolasetron / Drug dosages / Emergence agitation / Emergence Delirium - epidemiology / Emergence Delirium - etiology / Emergence Delirium - prevention & control / Emergency Medicine / Extubation / Female / Fentanyl / General anesthesia / Hemodynamics / Hospital costs / Humans / Hypertension / Intensive / Internal Medicine / Male / Medical societies / Medicine / Medicine & Public Health / Middle Aged / Nasal surgery / Nasal Surgical Procedures - adverse effects / Nasal Surgical Procedures - methods / Patients / Remifentanil / Respiration / Software / Surgery / Wakefulness / Young Adult