Journal Article

NSF DARE—transforming modeling in neurorehabilitation: a patient-in-the-loop framework

Song, Seungmoon, Miller, Haylie L., Zhang, Haohan, Allen, Jessica L., Chou, Amber Hsiao-Yang, Price, Mark A., Lin, David J., Secerovic, Natalija K., Cashaback, Joshua G. A.

2024

Overview

In 2023, the National Science Foundation (NSF) and the National Institute of Health (NIH) brought together engineers, scientists, and clinicians by sponsoring a conference on computational modelling in neurorehabiilitation. To facilitate multidisciplinary collaborations and improve patient care, in this perspective piece we identify where and how computational modelling can support neurorehabilitation. To address the where, we developed a patient-in-the-loop framework that uses multiple and/or continual measurements to update diagnostic and treatment model parameters, treatment type, and treatment prescription, with the goal of maximizing clinically-relevant functional outcomes. This patient-in-the-loop framework has several key features: (i) it includes diagnostic and treatment models, (ii) it is clinically-grounded with the International Classification of Functioning, Disability and Health (ICF) and patient involvement, (iii) it uses multiple or continual data measurements over time, and (iv) it is applicable to a range of neurological and neurodevelopmental conditions. To address the how, we identify state-of-the-art and highlight promising avenues of future research across the realms of sensorimotor adaptation, neuroplasticity, musculoskeletal, and sensory & pain computational modelling. We also discuss both the importance of and how to perform model validation, as well as challenges to overcome when implementing computational models within a clinical setting. The patient-in-the-loop approach offers a unifying framework to guide multidisciplinary collaboration between computational and clinical stakeholders in the field of neurorehabilitation.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adaptation / Biomedical and Life Sciences / Biomedical Engineering and Bioengineering / Biomedicine / Clinical decision making / Clinical outcomes / Collaboration / Computational modeling / Computational neuroscience / Computer simulation / Computer-generated environments / Diagnostic systems / Digital Twin / Disabled Persons / Engineering research / Glucose / Humans / Insulin / Interdisciplinary research / Medical research / Medicine, Experimental / Methods / Musculoskeletal / Neurological Rehabilitation / Neurology / Neuroplasticity / Neurosciences / NSF DARE Conference: Transformative Opportunities for Modeling in Neurorehabilitation / Patient satisfaction / Patient-in-the-loop / Patients / Physical therapists / Quality of life / Rehabilitation / Rehabilitation Medicine / Review / Sensorimotor adaptation / Sensorimotor system / Therapy