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AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study
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AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study
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AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study
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Journal Article
AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study
2018
Overview
Background
AB0 blood groups and Rhesus factor expression have been associated with carcinogenesis, response to treatment and tumor progression in several malignancies. The aim of the present study was to test the hypothesis that AB0 blood groups and Rhesus factor expression are associated with clinical outcome in patients with epithelial ovarian cancer (EOC).
Methods
AB0 blood groups and Rhesus factor expression were evaluated in a retrospective multicenter study including 518 patients with EOC. Their association with patients’ survival was assessed using univariate and multivariable analyses.
Results
Neither AB0 blood groups nor Rhesus factor expression were associated with clinico-pathological parameters, recurrence-free, cancer-specific, or overall survival. In a subgroup of patients with high-grade serous adenocarcinoma, however, blood groups B and AB were associated with a better 5-year cancer-specific survival rate compared to blood groups A and 0 (60.3 ± 8.6% vs. 43.8 ± 3.6%,
p
= 0.04). Yet, this was not significant in multivariable analysis.
Conclusions
AB0 blood groups and Rhesus factor expression are both neither associated with features of biologically aggressive disease nor clinical outcome in patients with EOC. Further investigation of the role of the blood group B antigen on cancer-specific survival in the subgroup of high-grade serous should be considered.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ ABO Blood-Group System - blood
/ ABO Blood-Group System - genetics
/ Aged
/ Analysis
/ Biomedical and Life Sciences
/ Carcinoma, Ovarian Epithelial - blood
/ Carcinoma, Ovarian Epithelial - mortality
/ Carcinoma, Ovarian Epithelial - pathology
/ Carcinoma, Ovarian Epithelial - therapy
/ Female
/ Health Promotion and Disease Prevention
/ Humans
/ Oncology
/ Outcome
/ Rh-Hr Blood-Group System - blood
/ Rh-Hr Blood-Group System - genetics
/ Survival
