Journal Article

Predicting who has delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage using machine learning approach: a multicenter, retrospective cohort study

Yang, Cheng, Zhang, Li-bo, Wang, Wei, Ge, Sihan, Chen, Zhi, Chen, Junxin, Zuo, Chenghai, Li, Ronghao, Teng, Yue, Niu, Yin, Tan, Liang, Tao, Yihao, Wang, Hao

2024

Overview

Background Early prediction of delayed cerebral ischemia (DCI) is critical to improving the prognosis of aneurysmal subarachnoid hemorrhage (aSAH). Machine learning (ML) algorithms can learn from intricate information unbiasedly and facilitate the early identification of clinical outcomes. This study aimed to construct and compare the ability of different ML models to predict DCI after aSAH. Then, we identified and analyzed the essential risk of DCI occurrence by preoperative clinical scores and postoperative laboratory test results. Methods This was a multicenter, retrospective cohort study. A total of 1039 post-operation patients with aSAH were finally included from three hospitals in China. The training group contained 919 patients, and the test group comprised 120 patients. We used five popular machine-learning algorithms to construct the models. The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, precision, and f1 score were used to evaluate and compare the five models. Finally, we performed a Shapley Additive exPlanations analysis for the model with the best performance and significance analysis for each feature. Results A total of 239 patients with aSAH (23.003%) developed DCI after the operation. Our results showed that in the test cohort, Random Forest (RF) had an AUC of 0.79, which was better than other models. The five most important features for predicting DCI in the RF model were the admitted modified Rankin Scale, D-Dimer, intracranial parenchymal hematoma, neutrophil/lymphocyte ratio, and Fisher score. Interestingly, clamping or embolization for the aneurysm treatment was the fourth button-down risk factor in the ML model. Conclusions In this multicenter study, we compared five ML methods, among which RF performed the best in DCI prediction. In addition, the essential risks were identified to help clinicians monitor the patients at high risk for DCI more precisely and facilitate timely intervention.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Aged / Algorithms / Aneurysm / Aneurysmal subarachnoid hemorrhage / Aneurysms / Blood / Blood platelets / Brain Ischemia - diagnosis / Brain Ischemia - epidemiology / Brain Ischemia - etiology / Cerebral ischemia / China - epidemiology / Cohort analysis / Cohort Studies / Decision trees / Delayed cerebral ischemia / Diagnosis / Embolization / Female / Glasgow Coma Scale / Hematoma / Hemorrhage / Hospitals / Humans / Ischemia / Laboratories / Learning algorithms / Leukocytes (neutrophilic) / Lymphocytes / Machine Learning / Male / Medicine / Medicine & Public Health / Middle Aged / Neurochemistry / Neurology / Neurosurgery / Neutrophils / Patients / Prediction / Prognosis / Random forest / Retrospective Studies / Risk factors / Stroke / Subarachnoid hemorrhage / Subarachnoid Hemorrhage - complications / Subarachnoid Hemorrhage - diagnosis / Subarachnoid Hemorrhage - epidemiology / Support vector machines