Asset Details
Do you wish to reserve the book?
Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?
Do you wish to request the book?
Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?
2022
Overview
Opioid-induced hyperalgesia (OIH) is a state of paradoxically enhanced pain transmission, termed nociceptive sensitization, described to occur in both humans and animals after repeated administration of opioid drugs, including rapidly acting remifentanil. However, molecular mechanisms of OIH remain understudied. In this issue of the JCI, Yan Jin and colleagues provided strong evidence that hyperexcitable thalamocortical networks drive remifentanil-induced hyperalgesia in a rodent model of postsurgical pain. Furthermore, the authors specifically identified an important role of the CaV3.1 isoform of low-voltage-activated or T-type calcium channels (T-channels) in this process. Further experiments are needed to determine whether thalamic T channels could serve as targets for the treatment of OIH.
Publisher
American Society for Clinical Investigation
Subject
/ Analgesics, Opioid - adverse effects
/ Animals
/ Calcium channels (voltage-gated)
/ Calcium Channels, T-Type - genetics
/ Calcium Channels, T-Type - therapeutic use
/ Complications and side effects
/ Drugs
/ Humans
/ Hyperalgesia - chemically induced
/ Opioids
/ Pain
/ Remifentanil - adverse effects
/ Thalamus
