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Patient-derived xenograft (PDX) models, applications and challenges in cancer research

by Saleh, Mahshid , Muhammadnejad, Samad , Baghaei, Kaveh , Asadzadeh Aghdaei, Hamid , Abdolahi, Shahrokh , Ghazvinian, Zeinab

in Animal models in research / Animals / Antitumor agents / Avatar model of cancer / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer animal model / Cancer microenvironment / Cancer research / Cancer therapies / Chemotherapy / Clinical trials / COVID-19 / Disease Models, Animal / Drug development / Drugs / Gene expression / Heterografts / Humanized model / Humans / Immune system / Immunotherapy / Medical research / Medicine/Public Health / Neoplasms - pathology / Patient outcomes / Patients / PDX / Precision medicine / Precision Medicine - methods / Preclinical study / Prevention / Review / Success / Transplants & implants / Tumor Microenvironment / Tumors / Validity / Xenograft Model Antitumor Assays / Xenografts / Xenotransplantation

2022

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Patient-derived xenograft (PDX) models, applications and challenges in cancer research

by Saleh, Mahshid , Muhammadnejad, Samad , Baghaei, Kaveh , Asadzadeh Aghdaei, Hamid , Abdolahi, Shahrokh , Ghazvinian, Zeinab

2022

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Patient-derived xenograft (PDX) models, applications and challenges in cancer research

by Saleh, Mahshid , Muhammadnejad, Samad , Baghaei, Kaveh , Asadzadeh Aghdaei, Hamid , Abdolahi, Shahrokh , Ghazvinian, Zeinab

2022

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Journal Article

Patient-derived xenograft (PDX) models, applications and challenges in cancer research

Saleh, Mahshid,

Muhammadnejad, Samad,

Baghaei, Kaveh,

Asadzadeh Aghdaei, Hamid,

Abdolahi, Shahrokh,

Ghazvinian, Zeinab

2022

Overview

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Animal models in research

/ Animals

/ Antitumor agents

/ Avatar model of cancer

/ Biomedical and Life Sciences

/ Biomedicine

/ Cancer