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Mechanisms of enhancer action: the known and the unknown
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Journal Article
Mechanisms of enhancer action: the known and the unknown
2021
Overview
Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential gene expression programs are the enhancers, the gene-distal
cis
-regulatory sequences that govern spatiotemporal and quantitative expression dynamics of target genes. Enhancers are widely believed to physically contact the target promoters to effect transcriptional activation. However, our understanding of the full complement of regulatory proteins and the definitive mechanics of enhancer action is incomplete. Here, we review recent findings to present some emerging concepts on enhancer action and also outline a set of outstanding questions.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Animals
/ Biomedical and Life Sciences
/ Chromatin Assembly and Disassembly
/ Complement regulatory proteins
/ DNA
/ DNA-Binding Proteins - metabolism
/ genome
/ Genome-Wide Association Study
/ Genomes
/ Genomics
/ Humans
/ Introns
/ Microbial Genetics and Genomics
/ Mutation
/ Ontogeny
/ Proteins
/ Regulatory Sequences, Nucleic Acid
/ Review
