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Brief diesel exhaust exposure acutely impairs functional brain connectivity in humans: a randomized controlled crossover study
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Brief diesel exhaust exposure acutely impairs functional brain connectivity in humans: a randomized controlled crossover study
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Journal Article
Brief diesel exhaust exposure acutely impairs functional brain connectivity in humans: a randomized controlled crossover study
2023
Overview
Background
While it is known that exposure to traffic-related air pollution causes an enormous global toll on human health, neurobiological underpinnings therein remain elusive. The study addresses this gap in knowledge.
Methods
We performed the first controlled human exposure study using functional MRI with an efficient order-randomized double-blind crossover study of diesel exhaust (DE) and control (filtered air; FA) in 25 healthy adults (14 males, 11 females; 19–49 years old; no withdrawals). Analyses were carried out using a mixed effects model in FLAME. Z (Gaussianised T/F) statistic images were thresholded non-parametrically using clusters determined by Z > 2.3 and a (corrected) cluster significance threshold of
p
= 0.05.
Results
All 25 adults went through the exposures and functional MRI imaging were collected. Exposure to DE yielded a decrease in functional connectivity compared to exposure to FA, shown through the comparison of DE and FA in post-exposure measurement of functional connectivity.
Conclusion
We observed short-term pollution-attributable decrements in default mode network functional connectivity. Decrements in brain connectivity causes many detrimental effects to the human body so this finding should guide policy change in air pollution exposure regulation.
Trial registration
University of British Columbia Clinical Research Ethics Board (# H12-03025), Vancouver Coastal Health Ethics Board (# V12-03025), and Health Canada’s Research Ethics Board (# 2012-0040).
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Air Pollutants - adverse effects
/ Air Pollution - adverse effects
/ Control
/ Earth and Environmental Science
/ Female
/ Functional magnetic resonance imaging (MRI)
/ Humans
/ Male
/ Methods
/ Occupational Medicine/Industrial Medicine
/ Particulate Matter - adverse effects
/ Vehicle Emissions - analysis
