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Nanodiscs for structural and functional studies of membrane proteins
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Journal Article
Nanodiscs for structural and functional studies of membrane proteins
2016
Overview
The use of nanodiscs is substantially fostering structural and functional studies of membrane protein. This Perspective summarizes the recent use of nanodiscs as an invaluable tool for the characterization of membrane proteins.
Membrane proteins have long presented a challenge to biochemical and functional studies. In the absence of a bilayer environment, individual proteins and critical macromolecular complexes may be insoluble and may display altered or absent activities. Nanodisc technology provides important advantages for the isolation, purification, structural resolution and functional characterization of membrane proteins. In addition, the ability to precisely control the nanodisc composition provides a nanoscale membrane surface for investigating molecular recognition events.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 631/535
/ Animals
/ Bilayers
/ Electron Spin Resonance Spectroscopy - methods
/ Humans
/ Membrane Proteins - chemistry
/ Membrane Proteins - isolation & purification
/ Membrane Proteins - ultrastructure
/ Microscopy, Electron - methods
/ Nuclear Magnetic Resonance, Biomolecular - methods
/ Proteins
