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Autophagy in mammalian development and differentiation
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Journal Article
Autophagy in mammalian development and differentiation
2010
Overview
It has been known for many decades that autophagy, a conserved lysosomal degradation pathway, is highly active during differentiation and development. However, until the discovery of the autophagy-related (
ATG
) genes in the 1990s, the functional significance of this activity was unknown. Initially, genetic knockout studies of
ATG
genes in lower eukaryotes revealed an essential role for the autophagy pathway in differentiation and development. In recent years, the analyses of systemic and tissue-specific knockout models of
ATG
genes in mice has led to an explosion of knowledge about the functions of autophagy in mammalian development and differentiation. Here we review the main advances in our understanding of these functions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
