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Identification and pathogenomic analysis of an Escherichia coli strain producing a novel Shiga toxin 2 subtype
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Identification and pathogenomic analysis of an Escherichia coli strain producing a novel Shiga toxin 2 subtype
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Journal Article
Identification and pathogenomic analysis of an Escherichia coli strain producing a novel Shiga toxin 2 subtype
2018
Overview
Shiga toxin (Stx) is the key virulent factor in Shiga toxin-producing
Escherichia coli
(STEC). To date, three Stx1 subtypes and seven Stx2 subtypes have been described in
E. coli
, which differed in receptor preference and toxin potency. Here, we identified a novel Stx2 subtype designated Stx2h in
E. coli
strains isolated from wild marmots in the Qinghai-Tibetan plateau, China. Stx2h shares 91.9% nucleic acid sequence identity and 92.9% amino acid identity to the nearest Stx2 subtype. The expression of Stx2h in type strain STEC299 was inducible by mitomycin C, and culture supernatant from STEC299 was cytotoxic to Vero cells. The Stx2h converting prophage was unique in terms of insertion site and genetic composition. Whole genome-based phylo- and patho-genomic analysis revealed STEC299 was closer to other pathotypes of
E. coli
than STEC, and possesses virulence factors from other pathotypes. Our finding enlarges the pool of Stx2 subtypes and highlights the extraordinary genomic plasticity of
E. coli
strains. As the emergence of new Shiga toxin genotypes and new Stx-producing pathotypes pose a great threat to the public health, Stx2h should be further included in
E. coli
molecular typing, and in epidemiological surveillance of
E. coli
infections.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/43
/ 45/77
/ 82
/ 82/1
/ Animals
/ China
/ E coli
/ Escherichia coli Infections - genetics
/ Escherichia coli Infections - microbiology
/ genome
/ Genomes
/ genomics
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Marmota
/ Science
/ Shiga Toxin 2 - isolation & purification
/ Shiga toxin-producing Escherichia coli
/ Shiga-Toxigenic Escherichia coli - genetics
/ Shiga-Toxigenic Escherichia coli - pathogenicity
/ Toxins
