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Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry
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Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry
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Journal Article
Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry
2018
Overview
The establishment of left–right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of
Drosophila
LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer’s vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry.
Left-right (LR) axis specification is essential for embryonic patterning but a unifying mechanism across organisms has not been identified. Here, the authors show that Myosin1D, known to regulate
Drosophila
LR asymmetry, controls zebrafish LR Organizer function, and is therefore a conserved regulator of animal laterality.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 64/116
/ 64/24
/ Animals
/ Animals, Genetically Modified
/ Cancer
/ Cilia
/ Embryo, Nonmammalian - embryology
/ Embryo, Nonmammalian - metabolism
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Left-Right Determination Factors - genetics
/ Left-Right Determination Factors - metabolism
/ Mutation
/ Myosin
/ Polarity
/ Science
