Journal Article

Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study

Crowley, J, Haessler, J, Orlowski, R, Goldschmidt, H, Hoering, A, Morgan, G, LeLeu, X, Feather, J, Sonneveld, P, Lahuerta, J J, Miguel, J S, Sezer, O, Rajkumar, S V, Lee, J H, Richardson, P G, Durie, B G M, Siegel, D, Moreau, P, Hulin, C, Jagannath, S, Klein, S K, Bladé, J, Palumbo, A, Kumar, S K

2012

Overview

Promising new drugs are being evaluated for treatment of multiple myeloma (MM), but their impact should be measured against the expected outcome in patients failing current therapies. However, the natural history of relapsed disease in the current era remains unclear. We studied 286 patients with relapsed MM, who were refractory to bortezomib and were relapsed following, refractory to or ineligible to receive, an IMiD (immunomodulatory drug), had measurable disease, and ECOG PS of 0, 1 or 2. The date patients satisfied the entry criteria was defined as time zero (T 0 ). The median age at diagnosis was 58 years, and time from diagnosis to T 0 was 3.3 years. Following T 0 , 213 (74%) patients had a treatment recorded with one or more regimens (median=1; range 0–8). The first regimen contained bortezomib in 55 (26%) patients and an IMiD in 70 (33%). A minor response or better was seen to at least one therapy after T 0 in 94 patients (44%) including ⩾partial response in 69 (32%). The median overall survival and event-free survival from T 0 were 9 and 5 months, respectively. This study confirms the poor outcome, once patients become refractory to current treatments. The results provide context for interpreting ongoing trials of new drugs.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: Adult / Aged / Aged, 80 and over / Antineoplastic Agents - administration & dosage / Antineoplastic Agents - therapeutic use / Biological and medical sciences / Bortezomib / Cancer Research / Cancer therapies / Clinical trials / Critical Care Medicine / Data collection / Development and progression / Disease Progression / Drug therapy / Drugs / Female / Health aspects / Hematologic and hematopoietic diseases / Hematology / Humans / Immunodeficiencies. Immunoglobulinopathies / Immunoglobulinopathies / Immunologic Factors - administration & dosage / Immunologic Factors - therapeutic use / Immunopathology / Intensive / Internal Medicine / Leukemia / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Male / Medical records / Medical research / Medical sciences / Medicine / Medicine & Public Health / Middle Aged / Multiple myeloma / Multiple Myeloma - drug therapy / Multiple Myeloma - pathology / Oncology / original-article / Patients / Recurrence / Response rates / Risk factors / Survival Analysis / Transplants & implants / Working groups