Journal Article

Epidemiological characteristics of tuberculosis incidence and its macro-influence factors in Chinese mainland during 2014–2021

Zhao, Fei, He, Guang-xue, Deng, Le-le, Zhang, Wei-wei, Li, Zhuo-wei, Ren, Xiang

2024

Overview

Background Tuberculosis (TB) remains a pressing public health issue, posing a significant threat to individuals' well-being and lives. This study delves into the TB incidence in Chinese mainland during 2014–2021, aiming to gain deeper insights into their epidemiological characteristics and explore macro-level factors to enhance control and prevention. Methods TB incidence data in Chinese mainland from 2014 to 2021 were sourced from the National Notifiable Disease Reporting System (NNDRS). A two-stage distributed lag nonlinear model (DLNM) was constructed to evaluate the lag and non-linearity of daily average temperature (℃, Atemp), average relative humidity (%, ARH), average wind speed (m/s, AWS), sunshine duration (h, SD) and precipitation (mm, PRE) on the TB incidence. A spatial panel data model was used to assess the impact of demographic, medical and health resource, and economic factors on TB incidence. Results A total of 6,587,439 TB cases were reported in Chinese mainland during 2014–2021, with an average annual incidence rate of 59.17/100,000. The TB incidence decreased from 67.05/100,000 in 2014 to 46.40/100,000 in 2021, notably declining from 2018 to 2021 (APC = -8.87%, 95% CI : -11.97, -6.85%). TB incidence rates were higher among males, farmers, and individuals aged 65 years and older. Spatiotemporal analysis revealed a significant cluster in Xinjiang, Qinghai, and Xizang from March 2017 to June 2019 ( RR  = 3.94, P  < 0.001). From 2014 to 2021, the proportion of etiologically confirmed cases increased from 31.31% to 56.98%, and the time interval from TB onset to diagnosis shortened from 26 days (IQR: 10–56 days) to 19 days (IQR: 7–44 days). Specific meteorological conditions, including low temperature (< 16.69℃), high relative humidity (> 71.73%), low sunshine duration (< 6.18 h) increased the risk of TB incidence, while extreme low wind speed (< 2.79 m/s) decreased the risk. The spatial Durbin model showed positive associations between TB incidence rates and sex ratio ( β  = 1.98), number of beds in medical and health institutions per 10,000 population ( β  = 0.90), and total health expenses ( β  = 0.55). There were negative associations between TB incidence rates and population ( β  = -1.14), population density ( β  = -0.19), urbanization rate ( β  = -0.62), number of medical and health institutions ( β  = -0.23), and number of health technicians per 10,000 population ( β  = -0.70). Conclusions Significant progress has been made in TB control and prevention in China, but challenges persist among some populations and areas. Varied relationships were observed between TB incidence and factors from meteorological, demographic, medical and health resource, and economic aspects. These findings underscore the importance of ongoing efforts to strengthen TB control and implement digital/intelligent surveillance for early risk detection and comprehensive interventions. Graphical Abstract

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Adolescent / Adult / Aged / Aged, 80 and over / Analysis / Child / Child, Preschool / China - epidemiology / Communicable diseases / Diseases / Distributed lag nonlinear model (DLNM) / East Asian People / Epidemiological characteristics / Epidemiology / Female / Health aspects / Humans / Humidity / Incidence / Infant / Infant, Newborn / Infectious Diseases / Influence factor / Male / Medicine / Medicine & Public Health / Middle Aged / Public Health / Reporting / Research Article / Risk Factors / Surveillance / Tropical Medicine / Tuberculosis / Tuberculosis - epidemiology / Tuberculosis - prevention & control / Young Adult