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Alternative splicing controls G protein–dependent inhibition of N-type calcium channels in nociceptors
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Alternative splicing controls G protein–dependent inhibition of N-type calcium channels in nociceptors
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Journal Article
Alternative splicing controls G protein–dependent inhibition of N-type calcium channels in nociceptors
2007
Overview
Neurotransmitter release from mammalian sensory neurons is controlled by Ca
V
2.2 N-type calcium channels. N-type channels are a major target of neurotransmitters and drugs that inhibit calcium entry, transmitter release and nociception through their specific G protein–coupled receptors. G protein–coupled receptor inhibition of these channels is typically voltage-dependent and mediated by Gβγ, whereas N-type channels in sensory neurons are sensitive to a second G protein–coupled receptor pathway that inhibits the channel independent of voltage. Here we show that preferential inclusion in nociceptors of exon 37a in rat
Cacna1b
(encoding Ca
V
2.2) creates,
de novo
, a C-terminal module that mediates voltage-independent inhibition. This inhibitory pathway requires tyrosine kinase activation but not Gβγ. A tyrosine encoded within exon 37a constitutes a critical part of a molecular switch controlling N-type current density and G protein–mediated voltage-independent inhibition. Our data define the molecular origins of voltage-independent inhibition of N-type channels in the pain pathway.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Analgesics, Opioid - pharmacology
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Calcium Channels, N-Type - physiology
/ Electric Stimulation - methods
/ Enkephalin, Ala-MePhe-Gly- - pharmacology
/ Enzyme Inhibitors - pharmacology
/ GABA Agonists - pharmacology
/ GTP-Binding Proteins - physiology
/ Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology
/ Humans
/ Kinases
/ Membrane Potentials - drug effects
/ Membrane Potentials - physiology
/ Membrane Potentials - radiation effects
/ Neural Inhibition - drug effects
/ Neural Inhibition - physiology
/ Neural Inhibition - radiation effects
/ Patch-Clamp Techniques - methods
/ Proteins
/ Rats
