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Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity
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Journal Article
Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity
2019
Overview
Hydrogen peroxide (H
2
O
2
) has a major function in host-microbial interactions. Although most studies have focused on the endogenous H
2
O
2
produced by immune cells to kill microbes, bacteria can also produce H
2
O
2
. How microbial H
2
O
2
influences the dynamics of host-microbial interactions is unclear. Here we show that H
2
O
2
released by
Streptococcus pneumoniae
inhibits inflammasomes, key components of the innate immune system, contributing to the pathogen colonization of the host. We also show that the oral commensal H
2
O
2
-producing bacteria
Streptococcus oralis
can block inflammasome activation. This study uncovers an unexpected role of H
2
O
2
in immune suppression and demonstrates how, through this mechanism, bacteria might restrain the immune system to co-exist with the host.
The functions of microbial hydrogen peroxide (H
2
O
2
) in host-pathogen interactions are unclear. Here, Erttmann and Gekara show that H
2
O
2
released by
Streptococcus pneumoniae
inhibits inflammasomes, and thereby contributes to the pathogen’s ability to colonize the host.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/1
/ 38/77
/ 64
/ 64/60
/ 82/1
/ 82/29
/ 82/51
/ 96
/ Animals
/ Bacteria
/ CARD Signaling Adaptor Proteins - genetics
/ CARD Signaling Adaptor Proteins - metabolism
/ Host Microbial Interactions - immunology
/ Humanities and Social Sciences
/ Humans
/ Hydrogen Peroxide - immunology
/ Hydrogen Peroxide - metabolism
/ Immunity
/ Mice
/ Science
/ Streptococcus oralis - immunology
/ Streptococcus oralis - metabolism
/ Streptococcus oralis - pathogenicity
/ Streptococcus pneumoniae - immunology
