Asset Details
Do you wish to reserve the book?
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
Do you wish to request the book?
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
2009
Overview
Circadian clocks coordinate behavioral and physiological processes with daily light-dark cycles by driving rhythmic transcription of thousands of genes. Whereas the master clock in the brain is set by light, pacemakers in peripheral organs, such as the liver, are reset by food availability, although the setting, or \"entrainment,\" mechanisms remain mysterious. Studying mouse fibroblasts, we demonstrated that the nutrient-responsive adenosine monophosphate-activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1). In mouse livers, AMPK activity and nuclear localization were rhythmic and inversely correlated with CRY1 nuclear protein abundance. Stimulation of AMPK destabilized cryptochromes and altered circadian rhythms, and mice in which the AMPK pathway was genetically disrupted showed alterations in peripheral clocks. Thus, phosphorylation by AMPK enables cryptochrome to transduce nutrient signals to circadian clocks in mammalian peripheral organs.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Aminoimidazole Carboxamide - analogs & derivatives
/ Aminoimidazole Carboxamide - pharmacology
/ AMP-activated protein kinase
/ AMP-Activated Protein Kinases - metabolism
/ Animals
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Biological and medical sciences
/ brain
/ Cells
/ Circadian Rhythm - physiology
/ Clocks
/ Food
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Genetics
/ Humans
/ Kinases
/ light
/ Liver
/ Mice
/ Mutant Proteins - metabolism
/ Recombinant Fusion Proteins - metabolism
/ Ribonucleotides - pharmacology
/ Rodents
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
