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Triage-driven diagnosis of Barrett’s esophagus for early detection of esophageal adenocarcinoma using deep learning
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Triage-driven diagnosis of Barrett’s esophagus for early detection of esophageal adenocarcinoma using deep learning
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Journal Article
Triage-driven diagnosis of Barrett’s esophagus for early detection of esophageal adenocarcinoma using deep learning
2021
Overview
Deep learning methods have been shown to achieve excellent performance on diagnostic tasks, but how to optimally combine them with expert knowledge and existing clinical decision pathways is still an open challenge. This question is particularly important for the early detection of cancer, where high-volume workflows may benefit from (semi-)automated analysis. Here we present a deep learning framework to analyze samples of the Cytosponge-TFF3 test, a minimally invasive alternative to endoscopy, for detecting Barrett’s esophagus, which is the main precursor of esophageal adenocarcinoma. We trained and independently validated the framework on data from two clinical trials, analyzing a combined total of 4,662 pathology slides from 2,331 patients. Our approach exploits decision patterns of gastrointestinal pathologists to define eight triage classes of varying priority for manual expert review. By substituting manual review with automated review in low-priority classes, we can reduce pathologist workload by 57% while matching the diagnostic performance of experienced pathologists.
A clinician-in-the-loop deep learning system streamlines the workflow of pathologists for detection of Barrett’s esophagus and retains the diagnostic accuracy of full manual review.
Publisher
Nature Publishing Group US,Nature Publishing Group
