Journal Article

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Clair, David St, Feng, Guoyin, Wang, Qingzhong, Collier, David A, Shi, Yongyong, Shen, Jiawei, Ji, Jue, Li, Tao, He, Lin, Steinberg, Stacy, Nöthen, Markus M, Li, Zhiqiang, Rietschel, Marcella, Wang, Ti, Liu, Dengtang, Zhang, Fengyu, Wang, Peng, Li, Baojie, Cichon, Sven, Xu, Qi, Stefansson, Kari, Zhang, Hairong, Chen, Jianhua, Wan, Chunling, Liu, Benxiu, Palotie, Aarno, Xu, Yifeng, Yang, Ping, Li, Wenjin, Zheng, Linqing, Tosato, Sarah, Ophoff, Roel A, He, Guang, Sun, Wensheng, Sigurdsson, Engilbert, Zhou, Guoquan, Werge, Thomas, Stefansson, Hreinn, Qin, Shengying, Ji, Weidong, Rujescu, Dan

2011

Overview

Yongyong Shi, Lin He and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify two new susceptibility loci on 8p12 and 1q24.2. Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 −10 ) and 1q24.2 (rs10489202, P = 9.50 × 10 −9 ). Our findings provide new insights into the pathogenesis of schizophrenia.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/208/727/2000 / 692/699/476/1799 / Adult / Adult and adolescent clinical studies / Aged / Agriculture / Animal Genetics and Genomics / Asian People / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Cancer Research / Case-Control Studies / Chromosomes, Human, Pair 1 / Chromosomes, Human, Pair 8 / Classical genetics, quantitative genetics, hybrids / Confidence intervals / Female / Fundamental and applied biological sciences. Psychology / Gene Function / Genealogy / Genetic aspects / Genetic Loci / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Genomes / Human Genetics / Humans / letter / Male / Medical sciences / Mental disorders / Methods, theories and miscellaneous / Middle Aged / Pathogenesis / Polymorphism, Single Nucleotide / Principal Component Analysis / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Psychoses / Regression analysis / Risk Factors / Schizophrenia / Schizophrenia - genetics / Single nucleotide polymorphisms / World population / Young Adult