Asset Details
Do you wish to reserve the book?
Novel correlates of protection against pandemic H1N1 influenza A virus infection
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Novel correlates of protection against pandemic H1N1 influenza A virus infection
Do you wish to request the book?
Novel correlates of protection against pandemic H1N1 influenza A virus infection
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Novel correlates of protection against pandemic H1N1 influenza A virus infection
2019
Overview
Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths annually
1
,
2
. Seasonal influenza virus vaccines can prevent infection, but are rendered ineffective by antigenic drift. To provide improved protection from infection, novel influenza virus vaccines that target the conserved epitopes of influenza viruses, specifically those in the hemagglutinin stalk and neuraminidase, are currently being developed
3
. Antibodies against the hemagglutinin stalk confer protection in animal studies
4
,
5
–
6
. However, no data exist on natural infections in humans, and these antibodies do not show activity in the hemagglutination inhibition assay, the hemagglutination inhibition titer being the current correlate of protection against influenza virus infection
7
,
8
–
9
. While previous studies have investigated the protective effect of cellular immune responses and neuraminidase-inhibiting antibodies, additional serological correlates of protection from infection could aid the development of broadly protective or universal influenza virus vaccines
10
,
11
,
12
–
13
. To address this gap, we performed a household transmission study to identify alternative correlates of protection from infection and disease in naturally exposed individuals. Using this study, we determined 50% protective titers and levels for hemagglutination inhibition, full-length hemagglutinin, neuraminidase and hemagglutinin stalk-specific antibodies. Further, we found that hemagglutinin stalk antibodies independently correlated with protection from influenza virus infection.
Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Antigens
/ Biomedical and Life Sciences
/ Child
/ Epitopes
/ Female
/ Hemagglutination Inhibition Tests
/ Hemagglutinin Glycoproteins, Influenza Virus - immunology
/ Humans
/ Immune response (cell-mediated)
/ Infant
/ Influenza A Virus, H1N1 Subtype - immunology
/ Influenza, Human - epidemiology
/ Influenza, Human - immunology
/ Influenza, Human - prevention & control
/ Letter
/ Male
/ Pandemics - prevention & control
/ Vaccines
/ Viruses
