Asset Details
Do you wish to reserve the book?
Detoxification of coumarins by rumen anaerobic fungi: insights into microbial degradation pathways and agricultural applications
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Detoxification of coumarins by rumen anaerobic fungi: insights into microbial degradation pathways and agricultural applications
Do you wish to request the book?
Detoxification of coumarins by rumen anaerobic fungi: insights into microbial degradation pathways and agricultural applications
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Detoxification of coumarins by rumen anaerobic fungi: insights into microbial degradation pathways and agricultural applications
2025
Overview
Background
Coumarins are toxic phytochemicals found in a variety of plants and are known to limit microbial degradation and interfere with nutrient cycling. While the degradation of coumarins by fungi has been studied in an environmental context, little is known about their degradation in the gastrointestinal system of herbivores after ingestion.
Results
In this study, we investigated in vitro fermentation by microbial enrichment, transcriptome sequencing, and high-resolution mass spectrometry to evaluate the ability of rumen anaerobic fungi to degrade coumarins. The results showed that despite the low abundance of anaerobic fungi in the rumen microbiota, they were able to effectively degrade coumarins. Specifically,
Pecoramyces ruminantium
F1 could tolerate coumarin concentrations up to 3 mmol/L and degrade it efficiently via metabolic pathways involving alpha/beta hydrolases and NAD(P)H oxidoreductases within the late growth phase. The fungus metabolized coumarin to less toxic compounds, including
o
-coumaric acid and melilotic acid, highlighting the detoxification potential of anaerobic fungi.
Conclusions
This study is the first to demonstrate the ability of rumen anaerobic fungi to degrade coumarin, providing new insights into the use of anaerobic fungi in sustainable agricultural practices and environmental detoxification strategies.
