Journal Article

Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China： A Multi-center Study

Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang

2015

Overview

Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit （NICU） stay in the mainland of China. Methods： All infants admitted to 26 NICUs with a birth weight （BW） 〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results： A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age （GA） was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants （23.3%） died and another 69 infants （26.7%） died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas （53.6% vs. 35.3%, P = 0.019）. BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions： Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.

• Publisher: Medknow Publications Pvt Ltd,Medknow Publications and Media Pvt. Ltd,Lippincott Williams & Wilkins Ovid Technologies,Department of Neonatal Intensive Care Unit, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310053, China%Department of Neonatology, Anhui Provincial Hospital, Hefei, Anhui 230001, China%Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China%Department of Neonatology, BaYi Children's Hospital of the General Military Hospital of Beijing People's Liberation Army, Beijing 100000, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer
• Subject: Birth weight / Children & youth / Childrens health / China / Demographic aspects / Disease / Extremely Low Birth Weight; Infant; Mortality; National Survey / Female / Health aspects / Hospitals / Humans / Infant / Infant Mortality / Infant, Extremely Low Birth Weight / Infant, Newborn / Intensive care / Intensive Care Units, Neonatal - statistics & numerical data / Low birth weight / Male / Maternal & child health / Medical prognosis / Medicine / Morbidity / Mortality / Newborn infants / NMR / Nosocomial infections / Nuclear magnetic resonance / Original / Pediatrics / Physiological aspects / Respiratory distress syndrome / Respiratory Distress Syndrome, Newborn - mortality / Retrospective Studies / Risk factors / Sepsis / Surveys and Questionnaires / Womens health / 中国内地 / 低出生体重 / 发病率 / 回归分析法 / 地极 / 多中心 / 平均体重 / 死亡率