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Host targets of candidalysin
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Journal Article
Host targets of candidalysin
2025
Overview
Candida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C. albicans hyphae secrete candidalysin, a cytolytic peptide toxin that damages host cells and activates immune responses. Candidalysin plays a key role in both pathogenicity and commensalism. In this Pearl, we review the host targets of candidalysin and how they modulate the interaction of C. albicans with the host.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Candida albicans - immunology
/ Candida albicans - metabolism
/ Candida albicans - pathogenicity
/ Complications and side effects
/ CRISPR
/ Enzymes
/ Fungal Proteins - immunology
/ Fungal Proteins - metabolism
/ Fungi
/ Host-Pathogen Interactions - immunology
/ Humans
/ Hyphae
/ Kinases
/ Medicine and Health Sciences
/ Pearls
/ Proteins
/ Research and Analysis Methods
/ Toxins
/ Vagina
