Asset Details
Do you wish to reserve the book?
The Implication and Significance of Beta 2 Microglobulin： A Conservative Multifunctional Regulator
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Implication and Significance of Beta 2 Microglobulin： A Conservative Multifunctional Regulator
Do you wish to request the book?
The Implication and Significance of Beta 2 Microglobulin： A Conservative Multifunctional Regulator
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Implication and Significance of Beta 2 Microglobulin： A Conservative Multifunctional Regulator
2016
Overview
Objective： This review focuses on the current knowledge on the implication and significance of beta 2 microglobulin （β2M）, a conservative immune molecule in vertebrate.Data Sources： The data used in this review were obtained from PubMed up to October 2015.Terms of β2M, immune response, and infection were used in the search.Study Selections： Articles related to β2M were retrieved and reviewed.Articles focusing on the characteristic and function of β2M were selected.The exclusion criteria of articles were that the studies on β2M-related molecules.Results： β2M is critical for the immune surveillance and modulation in vertebrate animals.The dysregulation of β2M is associated with multiple diseases, including endogenous and infectious diseases.β2M could directly participate in the development of cancer cells, and the level of β2M is deemed as a prognostic marker for several malignancies.It also involves in forming major histocompatibility complex （MHC class Ⅰ or MHC Ⅰ） or like heterodimers, covering from antigen presentation to immune homeostasis.Conclusions： Based on the characteristic of β2M, it or its signaling pathway has been targeted as biomedical or therapeutic tools.Moreover, β2M is highly conserved among different species, and overall structures are virtually identical, implying the versatility of β2M on applications.
Publisher
Wolters Kluwer - Medknow Publications,Medknow Publications and Media Pvt. Ltd,Lippincott Williams & Wilkins Ovid Technologies,Department of Food Quality and Safety, College of Food Science and Biotechnology, Tianjin Agricultural University, Tianjin 300384, China,Tianjin Engineering Research Center of Agricultural Products Processing, Tianjin 300384, China%Department of Clinical Laboratory, Wangdu Hospital of Traditional Chinese Medicine, Baoding, Hebei 072450, China%Department of Immunology and Microbiology, Anschutz Medical Campus, University of Colorado Denver,Aurora 80045, Colorado, USA,Medknow Publications & Media Pvt Ltd,Wolters Kluwer
Subject
/ B cells
/ beta 2-Microglobulin - blood
/ beta 2-Microglobulin - chemistry
/ beta 2-Microglobulin - deficiency
/ beta 2-Microglobulin - physiology
/ Cancer
/ Genes
/ Genomics
/ Hemochromatosis Protein - analysis
/ Histocompatibility Antigens Class I - physiology
/ Humans
/ Mutation
/ Proteins
/ Review
/ Traditional Chinese medicine
/ β2微球蛋白
/ 保守
/ 免疫分子
/ 多功能
/ 生物医学
/ 脊椎动物
/ 调节器
