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Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies
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Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies
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Journal Article
Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies
2016
Overview
Background
Studies examining the association between alcohol intake and the risk of pancreatic cancer have given inconsistent results. The purpose of this study was to summarize and examine the evidence regarding the association between alcohol intake and pancreatic cancer risk based on results from prospective cohort studies.
Methods
We searched electronic databases consisting of PubMed, Ovid, Embase, and the Cochrane Library identifying studies published up to Aug 2015. Only prospective studies that reported effect estimates with 95 % confidence intervals (CIs) for the risk of pancreatic cancer, examining different alcohol intake categories compared with a low alcohol intake category were included. Results of individual studies were pooled using a random-effects model.
Results
We included 19 prospective studies (21 cohorts) reporting data from 4,211,129 individuals. Low-to-moderate alcohol intake had little or no effect on the risk of pancreatic cancer. High alcohol intake was associated with an increased risk of pancreatic cancer (risk ratio [RR], 1.15; 95 % CI: 1.06–1.25). Pooled analysis also showed that high liquor intake was associated with an increased risk of pancreatic cancer (RR, 1.43; 95 % CI: 1.17–1.74). Subgroup analyses suggested that high alcohol intake was associated with an increased risk of pancreatic cancer in North America, when the duration of follow-up was greater than 10 years, in studies scored as high quality, and in studies with adjustments for smoking status, body mass index, diabetes mellitus, and energy intake..
Conclusions
Low-to-moderate alcohol intake was not significantly associated with the risk of pancreatic cancer, whereas high alcohol intake was associated with an increased risk of pancreatic cancer. Furthermore, liquor intake in particular was associated with an increased risk of pancreatic cancer.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
Alcohol Drinking - adverse effects
/ Alcohol Drinking - epidemiology
/ Alcohol Drinking - pathology
/ Biomedical and Life Sciences
/ Complications and side effects
/ Diabetes Mellitus - epidemiology
/ Diabetes Mellitus - pathology
/ Female
/ Health Promotion and Disease Prevention
/ Humans
/ Male
/ Oncology
/ Pancreatic Neoplasms - chemically induced
/ Pancreatic Neoplasms - epidemiology
/ Pancreatic Neoplasms - pathology
