Asset Details
Do you wish to reserve the book?
Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients
Do you wish to request the book?
Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients
2019
Overview
Background
The
Foxo3
gene, belonging to the forkhead family, is one of the classes of transcription factors characterized by a forkhead DNA-binding domain, which usually considered being a cancer suppressor gene.
Circ-Foxo3
is a circular structure which connects the 3’end to the 5’end. Scholars detected that
circ-Foxo3
could compete with
Foxo3
for binding to some miRNAs.
Methods
In this study, we will test the expression of
Foxo3
and
circ-Foxo3
in de novo acute myeloid leukemia (AML) patients to explore the relationship between
Foxo3
gene and
circ-Foxo3
. All the de novo AML samples and normal control samples was measured by real-time quantitative PCR. A receiver operating characteristic curve was conducted to differentiate AML patients from control people. Association of
Foxo3
expression and overall survival was conducted by Kaplan-Meier survival analysis.
Results
We found that the expression of
Foxo3
gene in de novo patients was significantly lower than control samples (
P
= 0.009). Meanwhile,
circ-Foxo3
also expressed lower in de novo AML patients than in control samples (
P
= 0.040). In different classifications, this trend could be observed more remarkably. In non-M3 patients, the
Foxo3
high patients’ survival time was longer than
Foxo3
low patients (
P
= 0.002). Besides, in non-favorable risk groups, patients with low expression of
Foxo3
had longer survival time than
Foxo3
high patients (
P
= 0.004). Furthermore, in normal Karyotypic patients, the overall survival time of patients with high-expressed
Foxo3
was significantly longer than those with low expression (
P
= 0.034). Besides, Pearson analysis was also conducted between these two genes in AML patients. Results revealed that they were positively correlated (R = 0.63,
P
< 0.001).
Conclusion
In conclusion, we found that low expression of
circ-Foxo3
and
Foxo3
were frequent in AML patients, and patients with high expression of
Foxo3
often had a trend of better prognosis.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aged
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Biomedical and Life Sciences
/ Child
/ Circular RNA, acute myeloid leukemia
/ DNA
/ Female
/ Forkhead Box Protein O3 - genetics
/ Forkhead Box Protein O3 - metabolism
/ Foxo3
/ Genes
/ Health Promotion and Disease Prevention
/ Humans
/ Leukemia
/ Leukemia, Myeloid, Acute - diagnosis
/ Leukemia, Myeloid, Acute - genetics
/ Leukemia, Myeloid, Acute - metabolism
/ Leukemia, Myeloid, Acute - mortality
/ Male
/ MicroRNA
/ Mutation
/ Oncology
/ RNA
/ Survival
