Asset Details
Do you wish to reserve the book?
Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
Do you wish to request the book?
Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
2010
Overview
Many symptoms induced by isolation rearing of rodents may be relevant to neuropsychiatric disorders, including depression. However, identities of transcription factors that regulate gene expression in response to chronic social isolation stress remain elusive. The transcription factor ATF‐7 is structurally related to ATF‐2, which is activated by various stresses, including inflammatory cytokines. Here, we report that
Atf‐7
‐deficient mice exhibit abnormal behaviours and increased 5‐HT receptor 5B (
Htr5b
) mRNA levels in the dorsal raphe nuclei. ATF‐7 silences the transcription of
Htr5B
by directly binding to its 5′‐regulatory region, and mediates histone H3‐K9 trimethylation via interaction with the ESET histone methyltransferase. Isolation‐reared wild‐type (WT) mice exhibit abnormal behaviours that resemble those of
Atf‐7
‐deficient mice. Upon social isolation stress, ATF‐7 in the dorsal raphe nucleus is phosphorylated via p38 and is released from the
Htr5b
promoter, leading to the upregulation of
Htr5b
. Thus, ATF‐7 may have a critical role in gene expression induced by social isolation stress.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,EMBO Press,Nature Publishing Group
Subject
/ Activating Transcription Factor 2 - metabolism
/ Activating Transcription Factors - chemistry
/ Activating Transcription Factors - deficiency
/ Activating Transcription Factors - genetics
/ Activating Transcription Factors - metabolism
/ Animals
/ ATF-7
/ EMBO09
/ EMBO27
/ Male
/ Mice
/ Receptors, Serotonin - genetics
/ Rodents
/ Stress
