Journal Article

Effect of microwave ablation treatment of hepatic malignancies on serum cytokine levels

Li, Qiang, Muktiali, Merlin, Li, Dapeng, Zhao, Jing, Ren, Bingjie, Li, Zhi, Tao, Min, Liang, Rongrui, Xie, Yufeng, Li, Daoming, Hu, Yingxi

2020

Overview

Background Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, and a limited number of studies indicate that ablation can cause not only necrosis at the in situ site but also an immunoreaction of the whole body. This study aimed to investigate the effects of MWA on cytokines in patients who underwent MWA for a hepatic malignancy. Methods Patients admitted to the Oncology Department in the First Affiliated Hospital of Soochow University between June 2015 and February 2019 were selected. Peripheral blood was collected from patients with a hepatic malignancy treated with MWA. The levels of cytokines (IL-2, IFN-γ, TNF-α, IL-12 p40, IL-12 p70, IL-4, IL-6, IL-8, IL-10, and vascular endothelial growth factor (VEGF)) were detected with a Milliplex® MAP Kit. The comparison times were as follows: before ablation, 24 h after ablation, 15 days after ablation, and 30 days after ablation. Data were analyzed using a paired sample t-tests and Spearman’s correlation analysis. Results A total of 43 patients with hepatic malignancies were assessed. There were significant differences in IL-2, IL-12 p40, IL-12 p70, IL-1β, IL-8, and TNF-α at 24 h after MWA. Significant increases (> 2-fold vs. before ablation) were observed in IL-2, IL-1β, IL-6, IL-8, IL-10, and TNF-α after MWA. Elevated IL-2 and IL-6 levels after ablation were positively correlated with energy output during the MWA procedure. Conclusions WA treatment for hepatic malignancies can alter the serum levels of several cytokines such as IL-2 and IL-6.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Ablation / Ablation (Surgery) / Ablation Techniques - adverse effects / Ablation Techniques - methods / Aged / Biomedical and Life Sciences / Biomedicine / Cancer / cancer imaging / Cancer Research / Cancer therapies / Care and treatment / Chemotherapy / Correlation analysis / Cytokines / EDTA / Energy output / Female / Health Promotion and Disease Prevention / Hepatic malignancy / Humans / IL-1β / IL-2 / IL-6 / Immunoregulation / Interleukin 10 / Interleukin 12 / Interleukin 2 / Interleukin 4 / Interleukin 6 / Interleukin 8 / Interleukin-2 - blood / Interleukin-2 - immunology / Interleukin-6 - blood / Interleukin-6 - immunology / interventional therapeutics / Liver / Liver - pathology / Liver - surgery / Liver cancer / Liver Neoplasms - pathology / Liver Neoplasms - surgery / Male / Malignancy / Medical research / Medicine/Public Health / Metastasis / Microwave ablation / Microwaves - adverse effects / Middle Aged / Mortality / Necrosis - blood / Necrosis - immunology / Oncology / Patients / Peripheral blood / Postoperative Period / Radiation therapy / Research Article / Serum levels / Statistical analysis / Surgical Oncology / Tumor necrosis factor-TNF / Tumor necrosis factor-α / Vascular endothelial growth factor / γ-Interferon