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Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy
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Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy
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Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy
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Journal Article
Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy
2020
Overview
Background
The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margin status and locoregional recurrence (LRR).
Methods
Our institutional prospectively maintained database was reviewed to identify patients who were treated with NACT between January 2008 and April 2018.
Results
Among the main partial mastectomy specimens available for analysis (
n
= 161), 28 had margins < 1 mm, 21 had margin width of 1–2 mm and the remaining 112 had margins > 2 mm. LRR occurred in 16 patients (9.9%) and distant metastases were detected in 27 (16.8%) patients. There was no significant difference in the LRR between the > 2 mm margin group with a 60-month cumulative survival of 85.2% compared with 76.2% for the ≤2 mm group (
P =
0.335) in the Kaplan-Meier analysis. When we stratified patients by margin widths of ≥1 mm or < 1 mm, there was no LRR-free survival benefit observed for the ≥1 mm pathologic excision margin group in the univariate analysis (hazard ratio = 0.443; 95% confidence interval = 0.142–1.383;
P =
0.161) with a 60-month cumulative LRR-free survival of 84.9% compared with 69.5% for the < 1 mm margin cohort (
P =
0.150).
Conclusions
In the absence of multiple scattered microscopic tumour foci, a negative margin of no ink on tumour maybe sufficient for stage I–III invasive breast cancer treated with NACT and breast-conserving surgery.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aged
/ Biomedical and Life Sciences
/ Biopsy
/ Breast Neoplasms - drug therapy
/ Breast Neoplasms - pathology
/ Carcinoma, Ductal, Breast - drug therapy
/ Carcinoma, Ductal, Breast - pathology
/ Carcinoma, Ductal, Breast - surgery
/ Carcinoma, Intraductal, Noninfiltrating - drug therapy
/ Carcinoma, Intraductal, Noninfiltrating - pathology
/ Carcinoma, Intraductal, Noninfiltrating - surgery
/ Female
/ Health Promotion and Disease Prevention
/ Humans
/ Mastectomy, Segmental - mortality
/ Neoadjuvant Therapy - mortality
/ Neoplasm Recurrence, Local - drug therapy
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - surgery
/ Oncology
/ Surgery
/ Survival
/ Tumors
