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Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
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Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
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Journal Article
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
2020
Overview
Background
This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients.
Methods
In this retrospective case series, intravitreal chemotherapy-assisted endoresection by pars plana vitrectomy was performed in 11 eyes with refractory ICRB group D retinoblastoma unresponsive to standard therapies in monocular patients.
Results
Across a mean follow-up period of 42.7 months, globe salvage was attained in all 11 eyes (100%). There were no cases of extra-ocular tumour seeding or remote metastasis. In 9 eyes (81.8%), tumour control was achieved with one pars plana vitrectomy; in 2 cases (18.2%), repeated treatment, such as laser therapy, intravitreal chemotherapy or a second pars plana vitrectomy, was needed. Retinal reattachment was achieved in all 4 eyes (100%) with previous retinal detachment. Four eyes (36.4%) required subsequent cataract surgery due to secondary cataract. Ten eyes (90.9%) had improvement in best-corrected visual acuity at the last follow-up.
Conclusion
Intravitreal chemotherapy-assisted endoresection appears to be a safe and effective globe-salvaging method for refractory group D retinoblastoma. It is a promising alternative to enucleation and a supplementary therapeutic strategy for those unresponsive to standard therapies, especially for the monocular retinoblastoma patients.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Cancer
/ Chemotherapy, Adjuvant - adverse effects
/ Chemotherapy, Adjuvant - methods
/ Child
/ Eye
/ Health Promotion and Disease Prevention
/ Humans
/ Infant
/ Lasers
/ Neoadjuvant Therapy - adverse effects
/ Neoadjuvant Therapy - methods
/ Neoplasm Recurrence, Local - epidemiology
/ Neoplasm Recurrence, Local - prevention & control
/ Oncology
/ Patients
/ Retina
/ Retinal Neoplasms - pathology
/ Salvage Therapy - adverse effects
/ Surgery
/ Topotecan - administration & dosage
/ Tumors
/ Vitrectomy - adverse effects
