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Neurobiological effects of gallic acid: current perspectives

by Hossain, Kazi Nadim , Calina, Daniela , Bappi, Mehedi Hasan , Sikder, Md. Iqbal , Rahaman, Md. Mizanur , Gürer, Eda Sönmez , Akter, Fatama , Rokonuzzman, Md , Islam, Muhammad Torequl , Islam, Tawhida , Bhuia, Md. Shimul , Al Shamsh Prottay, Abdullah , Sharifi-Rad, Javad

in Acupuncture / Alzheimer's disease / Analysis / Bioavailability / Brain health / Complementary & Alternative Medicine / Drug dosages / Drug therapy / Fatalities / Fruits / Gallic acid / Gallic acid; neuroprotective activity; pharmacological effects / Hydrocarbons / Inflammation / Ischemia / Laboratory animals / Medical research / Medicinal plants / Medicine / Medicine & Public Health / Medicine, Botanic / Medicine, Experimental / Medicine, Herbal / Metabolism / Metabolites / Molecular mechanisms / Movement disorders / Nanomaterials / Nanotechnology / Nervous system diseases / Neuralgia / Neurodegenerative diseases / Neurological diseases / Neuroprotection / Oils & fats / Parkinson's disease / Peptides / Pharmacokinetics / Pharmacology / Phenols / Polyphenols / Psychosis / Review / Traditional Chinese Medicine / Urine

2023

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2023

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2023

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Journal Article

Neurobiological effects of gallic acid: current perspectives

Hossain, Kazi Nadim,

Calina, Daniela,

Bappi, Mehedi Hasan,

Sikder, Md. Iqbal,

Rahaman, Md. Mizanur,

Gürer, Eda Sönmez,

Akter, Fatama,

Rokonuzzman, Md,

Islam, Muhammad Torequl,

Islam, Tawhida,

Bhuia, Md. Shimul,

Al Shamsh Prottay, Abdullah,

Sharifi-Rad, Javad

2023

Overview

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Acupuncture

/ Alzheimer's disease

/ Analysis

/ Bioavailability

/ Brain health

/ Complementary & Alternative Medicine

/ Drug dosages