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Long-term prognosis and treatment modalities of hepatic epithelioid hemangioendothelioma: a retrospective study of 228 patients
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Long-term prognosis and treatment modalities of hepatic epithelioid hemangioendothelioma: a retrospective study of 228 patients
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Long-term prognosis and treatment modalities of hepatic epithelioid hemangioendothelioma: a retrospective study of 228 patients
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Journal Article
Long-term prognosis and treatment modalities of hepatic epithelioid hemangioendothelioma: a retrospective study of 228 patients
2024
Overview
Background
Hepatic epithelioid hemangioendothelioma (EHE) is an extremely rare tumour. The aim of this study was to investigate the long-term prognosis and its relationship with treatment modalities.
Methods
From March 2014 to June 2024, a total of 234 patients with histologically confirmed hepatic EHE were treated or followed up regularly by our team. The patients’ clinical data at the time of diagnosis and initial treatment modalities were retrospectively collected. Kaplan–Meier curves were constructed to determine overall survival (OS). To explore prognostic factors and treatment outcomes, univariable and multivariable Cox proportional hazard models were developed.
Results
A total of 228 patients were ultimately included. The median age of the cohort was 41 years. For all patients, the OS of 1-, 3- and 5-year were 96.2%, 87.9% and 84.9%, respectively. For patients who underwent liver transplantation (LT), the OS of 1- and 3-year were 62.5% and 25%, respectively. No difference was found in the OS between patients who received surgical therapy and those who did not (1-year: 100% vs. 96.9%; 3-year: 90.1% vs. 91.5%; 5-year: 87.2% vs. 88.2%;
P
= 0.891). In the multivariable analysis, age ≥ 60 years [HR (95% CI): 4.207 (1.266–13.973),
P
= 0.019], the size of the largest lesion > 10 cm [HR (95% CI): 12.140 (1.419–103.872),
P
= 0.023] and LT [HR (95% CI): 5.502 (1.343–22.536),
P
= 0.018] were poor prognostic factors.
Conclusions
Compared with nonsurgical therapy, surgical therapy has no advantage in terms of long-term survival. The role of LT in the management of hepatic EHE should be reevaluated. Age ≥ 60 years and the size of the largest lesion > 10 cm are poor prognostic factors.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Age
/ Aged
/ Analysis
/ Biomedical and Life Sciences
/ Biopsy
/ Epithelioid hemangioendothelioma
/ Female
/ Health Promotion and Disease Prevention
/ Hemangioendothelioma, Epithelioid - diagnosis
/ Hemangioendothelioma, Epithelioid - mortality
/ Hemangioendothelioma, Epithelioid - pathology
/ Hemangioendothelioma, Epithelioid - therapy
/ Humans
/ Liver
/ Male
/ Materia medica and therapeutics
/ Oncology
/ Patients
/ Surgery
/ Survival
