Journal Article

Loss to follow-up and associated maternal factors among HIV-exposed infants at the Mbarara Regional Referral Hospital, Uganda: a retrospective study

Nkfusai, Claude Ngwayu, Kabanda, Taseera, Cumber, Samuel Nambile, Ankunda, Rogers, Turyakira, Eleanor, Wirsiy, Frankline Sevidzem, Atuhaire, Catherine

2020

Overview

Background Loss to follow-up (LTFU) deprives HIV-exposed infants the lifesaving care required and results in exposing HIV free infants to virus requisition risk. We aimed to determine the rate of LTFU, postnatal mother-to-child HIV-transmission (MTCT) and to identify maternal factors associated with LTFU among HIV-exposed infants enrolled at Mbarara Regional Referral Hospital PMTCT clinic. Methods Study participants were infants born to HIV-positive mothers enrolled in the PMTCT clinic for HIV care at Mbarara Regional Referral Hospital. While access database in the Early Infant Diagnosis (EID) clinic provided data on infants, the open medical record system database at the ISS clinic provided that for mothers. Infants were classified as LTFU if they had not completed their follow-up schedule by 18 months of age. At 18 months, an infant is expected to receive a rapid diagnostic test before being discharged from the PMTCT clinic. Postnatal MTCT of HIV was calculated as a proportion of infants followed and tested from birth to 18 months of age. Logistic regression was used to determine possible associations between mothers’ characteristics and LTFU. In-depth interviews of mothers of LTFU infants and health workers who attend to the HIV-exposed infants were carried out to identify factors not captured in the electronic database. Results Out of 1624 infants enrolled at the clinic, 533 (33%) were dropped for lack of mother’s clinic identification number, 18 (1.1%) were either dead or transferred out. Out of 1073 infants analysed, 515 (48%) were LTFU by 18 months of age while out of the 558 who completed their follow-up schedule, 20 (3.6%) tested positive for HIV. Young age of mother, far distance to hospital and non-use of family planning were identified as outstanding factors responsible for LTFU. In addition, in-depth interviews revealed facility-level factors such as “waiting time” which would not be found in routine client databases. Conclusion This study has revealed a high rate of loss to follow up among HIV-exposed infants enrolled at Mbarara Regional Referral hospital PMTCT clinic. Young maternal age, long distance to health facility and failure to use family planning were significantly associated with LTFU. Incorporating family planning services in the ART and PMTCT clinics could reduce loss to follow-up of HIV exposed infants. Young mothers should be targeted with information on the importance of completing the EID follow-up schedule and also, their clinic identification number be gotten at each visit.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Age / Age Factors / Ambulatory Care Facilities / Antiretroviral therapy / Babies / Breastfeeding & lactation / Building failures / Childbirth & labor / Children & youth / Data analysis / Data collection / Demographic aspects / Deoxyribonucleic acid / Diagnosis / Diagnostic systems / Disease transmission / DNA / Early Diagnosis / Exposure / Family planning / Family planning services / Female / Follow-Up Studies / Forecasts and trends / Health aspects / Health care facilities / HIV / HIV and co-infections / HIV infections / HIV Infections - diagnosis / HIV Infections - transmission / HIV patients / HIV tests / HIV-exposed infants / Hospital facilities / Human immunodeficiency virus / Humans / Infant / Infants / Infectious Disease Transmission, Vertical / Infectious Diseases / Internal Medicine / Loss to follow up / Lost to Follow-Up / Male / Medical Microbiology / Medical personnel / Medical records / Medical tests / Medicine / Medicine & Public Health / Mothers / Neonatal screening / Parasitology / Post-natal mother to child transmission / Pregnancy / Referral and Consultation / Regression analysis / Research Article / Retrospective Studies / Risk Factors / Schedules / Social services / Studies / Time / Tropical Medicine / Uganda / Variables / Viruses / Womens health / Workers / Young Adult