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Alteration of payload in extracellular vesicles by crosstalk with mesenchymal stem cells from different origin
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Alteration of payload in extracellular vesicles by crosstalk with mesenchymal stem cells from different origin
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Alteration of payload in extracellular vesicles by crosstalk with mesenchymal stem cells from different origin
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Journal Article
Alteration of payload in extracellular vesicles by crosstalk with mesenchymal stem cells from different origin
2021
Overview
Background
The application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) requires customized materials to target disease or cell damage. We hypothesized that EVs exert different inflammatory effects on one recipient cell, although stem cells of different origins in humans have similar payloads.
Results
Here, the payload of EVs released by crosstalk between MSCs and human middle ear epithelial cells (HMEECs) extracted from adipose tissue, bone marrow and tonsils significantly increased the level of anti-inflammatory factors. EVs derived from the co-culture medium decreased
TNF-α, COX-2, IL-1β
, and
IL-6
levels to approximately zero within 3 h in HMEECs. Expression of miR-638 and amyloid-β A4 precursor protein-binding family A member 2 was analyzed using microarrays and gene ontology analysis, respectively.
Conclusions
In conclusion, stem cells of different origins have different payloads through crosstalk with recipient-specific cells. Inducing specific factors in EVs by co-culture with MSCs could be valuable in regenerative medicine.
Graphical abstract
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
