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An atlas of B-cell clonal distribution in the human body
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An atlas of B-cell clonal distribution in the human body
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An atlas of B-cell clonal distribution in the human body
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Journal Article
An atlas of B-cell clonal distribution in the human body
2017
Overview
B-cell VH region repertoire sequencing of eight anatomical sites in six human donors reveals distinct networks of clone distribution.
B-cell responses result in clonal expansion, and can occur in a variety of tissues. To define how B-cell clones are distributed in the body, we sequenced 933,427 B-cell clonal lineages and mapped them to eight different anatomic compartments in six human organ donors. We show that large B-cell clones partition into two broad networks—one spans the blood, bone marrow, spleen and lung, while the other is restricted to tissues within the gastrointestinal (GI) tract (jejunum, ileum and colon). Notably, GI tract clones display extensive sharing of sequence variants among different portions of the tract and have higher frequencies of somatic hypermutation, suggesting extensive and serial rounds of clonal expansion and selection. Our findings provide an anatomic atlas of B-cell clonal lineages, their properties and tissue connections. This resource serves as a foundation for studies of tissue-based immunity, including vaccine responses, infections, autoimmunity and cancer.
