Asset Details
Do you wish to reserve the book?
Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers
Do you wish to request the book?
Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers
2020
Overview
Background
Burn injury is associated with a long-standing inflammatory reaction. The use of albumin solutions for plasma volume support is controversial because of concerns of increased capillary leakage, which could aggravate the commonly seen interstitial oedema.
Methods
In the present open controlled clinical trial, an intravenous infusion of 20% albumin at 3 mL/kg was given over 30 min to 15 burn patients and 15 healthy volunteers. Blood samples and urine were collected for 5 h. Plasma dilution, plasma albumin and colloid osmotic pressure were compared. Mass balance calculations were used to estimate plasma volume expansion and capillary leakage of fluid and albumin.
Results
The patients were studied between 4 and 14 (median, 7) days after the burn injury, which spread over 7–48% (median, 15%) of the total body surface area. The albumin solution expanded the plasma volume by almost 15%, equivalent to twice the infused volume, in both groups. The urinary excretion exceeded the infused volume by a factor of 2.5. Capillary leakage of albumin occurred at a rate of 3.4 ± 1.5 g/h in burn patients and 3.7 ± 1.6 g/h in the volunteers (
P
= 0.61), which corresponded to 2.4 ± 1.0% and 2.5 ± 1.2% per hour of the intravascular pool (
P
= 0.85). The median half-life of the plasma volume expansion was 5.9 (25th–75th percentiles 2.7–11.7) h in the burn patients and 6.9 (3.4–8.5) h in the volunteers (
P
= 0.56).
Conclusions
Albumin 20% was an effective volume expander in patients at 1 week post-burn. No relevant differences were found between burn patients and healthy volunteers.
Trial registration
EudraCT 2016-000996-26
on May 31, 2016.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Albumin
/ Blood
/ Burns
/ Burns (physiology), Capillary permeability (physiology)
/ Capillary Leak Syndrome - drug therapy
/ Capillary Leak Syndrome - etiology
/ Capillary Leak Syndrome - prevention & control
/ Edema
/ Female
/ Humans
/ Male
/ Medicine
/ Patients
/ Plasma
/ Plasma Substitutes - pharmacology
/ Plasma Substitutes - therapeutic use
/ Plasma Volume - drug effects
/ Serum albumin (pharmacokinetics, therapy)
/ Urine
